We developed and evaluated a photo captioning intervention aimed at increasing cognitive empathy and improving mental health and reducing inflammation in dementia caregivers, and to examine the neural and psychological mechanisms by which the intervention works. Caregivers experienced pre- to post-intervention increases in cognitive empathy (i.e., Perspective-Taking) and decreases in both burden and anxiety. These changes were paralleled by an increased neural response to photographs of their PLWD within brain regions implicated in cognitive empathy.